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【结 构 式】 
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【药物名称】SU-4984 【化学名称】(E)-4-[4-(2-Oxoindolin-3-ylidenemethyl)phenyl]piperazine-1-carbaldehyde 【CA登记号】186610-89-9 【 分 子 式 】C20H19N3O2 【 分 子 量 】333.39333 |
【开发单位】Sugen (Originator) 【药理作用】ONCOLYTIC DRUGS, FGFR1 Inhibitors, Inhibitors of Signal Transduction Pathways, Tyrosine Kinase Inhibitors |
合成路线1
The reaction of 1-phenylpiperazine (I) with DMF and POCl3 in dichloroethane gives 4-(4-formylpiperazin-1-yl)benzaldehyde (II), which is condensed with indolin-2-one (III) by means of piperidine in refluxing ethanol.
| 【1】 Sun, L.; et al.; Synthesis and biological evaluations of 3-substituted indolin-2-ones: A novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem 1998, 41, 14, 2588. |
| 【2】 Tang, P.C.; Sun, L.; McMahon, G. (Sugen, Inc.); Indolinone cpds. for the treatment of disease. EP 0769947; JP 2000026412; US 5780496; US 5792783; US 5880141; US 5883113; US 5883116; WO 9640116 . |
Extended Information