N,N-dimethylacetamide -Drug Synthesis Database

【结构式】

【分子编号】24751

【品名】N,N-dimethylacetamide

【CA登记号】127-19-5

【分子式】C₄H₉NO

【分子量】87.1216

【元素组成】C 55.15% H 10.41% N 16.08% O 18.36%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Iproplatin is prepared by treating cis-dichlorobis(isopropylamine)platinum (I) with hydrogen peroxide, mixing the product by N,N-dimetylacetamide at 5 C to give iproplatin-dimethylacetamide 1:1 addiction product (II). After elimination of N,N-dimethylacetamide by heating (II) at 50 C / 0.1 torr iproplatin is obtained.

参考文献中间体

合成目标

【1】 Hepburn, D.R.; Hydes, P.C. (Johnson Matthey plc); cis-Dichloro-trans-dihydroxy-bis(isopropylamine)platinum(IV), preparation and intermediate. BE 890209; JP 1982077694 .
【2】 Chang, P.; Iroplatin. Drugs Fut 1985, 10, 7, 561.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	24750	Bis(isopropylamine)dichloro platinum complex		C₆H₁₈Cl₂N₂Pt	详情	详情
(II)	24751	N,N-dimethylacetamide	127-19-5	C₄H₉NO	详情	详情
(III)	24752	Bis(isopropylamine)dichloro dihydroxo platinum complex with N,N-dimethylacetamide		C₁₀H₂₉Cl₂N₃O₃Pt	详情	详情

Extended Information