Iproplatin, NSC-256927, CHIP, JM-9, -Drug Synthesis Database

【结构式】

【药物名称】Iproplatin, NSC-256927, CHIP, JM-9

【化学名称】Dichlorodihydroxybis(2-propanamine)-(OC-6-33)platinum cis-Dichloro-trans-dihydroxybis(isopropylamine)platinum(IV)

【CA登记号】62928-11-4

【分子式】C₆H₂₀Cl₂N₂O₂Pt

【分子量】418.2345

【开发单位】Johnson Matthey (Originator), Bristol-Myers Squibb (Licensee)

【药理作用】ONCOLYTIC DRUGS, Platinum Complexes

合成路线1

Iproplatin is prepared by treating cis-dichlorobis(isopropylamine)platinum (I) with hydrogen peroxide, mixing the product by N,N-dimetylacetamide at 5 C to give iproplatin-dimethylacetamide 1:1 addiction product (II). After elimination of N,N-dimethylacetamide by heating (II) at 50 C / 0.1 torr iproplatin is obtained.

参考文献中间体

【1】 Hepburn, D.R.; Hydes, P.C. (Johnson Matthey plc); cis-Dichloro-trans-dihydroxy-bis(isopropylamine)platinum(IV), preparation and intermediate. BE 890209; JP 1982077694 .
【2】 Chang, P.; Iroplatin. Drugs Fut 1985, 10, 7, 561.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	24750	Bis(isopropylamine)dichloro platinum complex		C₆H₁₈Cl₂N₂Pt	详情	详情
(II)	24751	N,N-dimethylacetamide	127-19-5	C₄H₉NO	详情	详情
(III)	24752	Bis(isopropylamine)dichloro dihydroxo platinum complex with N,N-dimethylacetamide		C₁₀H₂₉Cl₂N₃O₃Pt	详情	详情

Extended Information