2-(1-piperazinyl)-1-ethanamine -Drug Synthesis Database

【结构式】

【分子编号】24647

【品名】2-(1-piperazinyl)-1-ethanamine

【CA登记号】140-31-8

【分子式】C₆H₁₅N₃

【分子量】129.20532

【元素组成】C 55.78% H 11.7% N 32.52%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Condensation of 2-amino-5-bromopyridine (I) with 1,1-thiocarbonyl diimidazole (II) furnished the thiocarbonyl derivative (III). Further reaction of (III) with 1-(2-aminoethyl)piperazine (IV) gave the target thiourea.

参考文献中间体

合成目标

【1】 Mao, C.; Vig, R.; Venkatachalam, T.K.; Sudbeck, E.A.; Uckun, F.M.; Structure-based design of N-[2-(1-piperidinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett 1998, 8, 16, 2213.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12123	5-Bromo-2-pyridinylamine; 5-Bromo-2-pyridinamine; 2-Amino-5-bromopyridine	1072-97-5	C₅H₅BrN₂	详情	详情
(II)	11990	Di(1H-imidazol-1-yl)methanethione; 1,1'-Thiocarbonyldiimidazole	6160-65-2	C₇H₆N₄S	详情	详情
(III)	24645	N-(5-bromo-2-pyridinyl)-1H-imidazole-1-carbothioamide		C₉H₇BrN₄S	详情	详情
(IV)	24647	2-(1-piperazinyl)-1-ethanamine	140-31-8	C₆H₁₅N₃	详情	详情

Extended Information