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【结 构 式】

【药物名称】

【化学名称】N-(5-bromo-2-pyridinyl)-N'-[2-(1-piperazinyl)ethyl]thiourea

【CA登记号】

【 分 子 式 】C12H18BrN5S

【 分 子 量 】344.27876

【开发单位】Parker Hughes Institute (Originator)

【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Reverse Transcriptase Inhibitors

合成路线1

Condensation of 2-amino-5-bromopyridine (I) with 1,1-thiocarbonyl diimidazole (II) furnished the thiocarbonyl derivative (III). Further reaction of (III) with 1-(2-aminoethyl)piperazine (IV) gave the target thiourea.

1 Mao, C.; Vig, R.; Venkatachalam, T.K.; Sudbeck, E.A.; Uckun, F.M.; Structure-based design of N-[2-(1-piperidinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett 1998, 8, 16, 2213.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 12123 5-Bromo-2-pyridinylamine; 5-Bromo-2-pyridinamine; 2-Amino-5-bromopyridine 1072-97-5 C5H5BrN2 详情 详情
(II) 11990 Di(1H-imidazol-1-yl)methanethione; 1,1'-Thiocarbonyldiimidazole 6160-65-2 C7H6N4S 详情 详情
(III) 24645 N-(5-bromo-2-pyridinyl)-1H-imidazole-1-carbothioamide C9H7BrN4S 详情 详情
(IV) 24647 2-(1-piperazinyl)-1-ethanamine 140-31-8 C6H15N3 详情 详情
Extended Information