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【结 构 式】 
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【药物名称】 【化学名称】N-(5-bromo-2-pyridinyl)-N'-[2-(1-piperazinyl)ethyl]thiourea 【CA登记号】 【 分 子 式 】C12H18BrN5S 【 分 子 量 】344.27876 |
【开发单位】Parker Hughes Institute (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Reverse Transcriptase Inhibitors |
合成路线1
Condensation of 2-amino-5-bromopyridine (I) with 1,1-thiocarbonyl diimidazole (II) furnished the thiocarbonyl derivative (III). Further reaction of (III) with 1-(2-aminoethyl)piperazine (IV) gave the target thiourea.
| 【1】 Mao, C.; Vig, R.; Venkatachalam, T.K.; Sudbeck, E.A.; Uckun, F.M.; Structure-based design of N-[2-(1-piperidinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett 1998, 8, 16, 2213. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12123 | 5-Bromo-2-pyridinylamine; 5-Bromo-2-pyridinamine; 2-Amino-5-bromopyridine | 1072-97-5 | C5H5BrN2 | 详情 | 详情 |
| (II) | 11990 | Di(1H-imidazol-1-yl)methanethione; 1,1'-Thiocarbonyldiimidazole | 6160-65-2 | C7H6N4S | 详情 | 详情 |
| (III) | 24645 | N-(5-bromo-2-pyridinyl)-1H-imidazole-1-carbothioamide | C9H7BrN4S | 详情 | 详情 | |
| (IV) | 24647 | 2-(1-piperazinyl)-1-ethanamine | 140-31-8 | C6H15N3 | 详情 | 详情 |
Extended Information