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【结 构 式】

【分子编号】24567

【品名】2-[(2-chlorophenoxy)methyl]oxirane

【CA登记号】

【 分 子 式 】C9H9ClO2

【 分 子 量 】184.62196

【元素组成】C 58.55% H 4.91% Cl 19.2% O 17.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The condensation of 2-glycidyloxy-1-chlorobenzene (I) with ethylenediamine (II) in refluxing ethanol gives N-[3-(2-chlorophenoxy)-2-hydroxy propyl]ethylenediamine (III), which is then condensed with 4,5-dichloropyridazinone (IV) in refluxing ethanol.

1 Raabe, T.; Bohn, H.; Martorana, P.A.; Nitz R.-E. (Cassella AG); N-phenoxypropanol-N'-pyridazinyl ethylendiamines as beta -receptor blockers. DD 202013; DE 3048487; EP 54946; JP 57128677; US 4532239 .
2 Castaner, J.; Prous, J.; Ridazolol. Drugs Fut 1986, 11, 12, 1044.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 24567 2-[(2-chlorophenoxy)methyl]oxirane C9H9ClO2 详情 详情
(II) 14754 ethylenediamine;1,2-Diaminoethane;ethane-1,2-diamine;1,2-Ethanediamine 107-15-3 C2H8N2 详情 详情
(III) 24569 1-[(2-aminoethyl)amino]-3-(2-chlorophenoxy)-2-propanol C11H17ClN2O2 详情 详情
(IV) 24570 4,5-dichloro-3(2H)-pyridazinone C4H2Cl2N2O 详情 详情
Extended Information