【结 构 式】 |
【分子编号】24350 【品名】(2S,3S)-2,3-oxiranedicarboxylic acid 【CA登记号】 |
【 分 子 式 】C4H4O5 【 分 子 量 】132.07276 【元素组成】C 36.38% H 3.05% O 60.57% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The synthesis of [14 C]-EST has been described ac cording to the following procedure: The oxidation of fumaric acid (I) with H2O2 gives trans-epoxysuccinic acid (II), which is submitted to optical resolution by means of its salt with L-arginine. The L-trans isomer (III) is esterified with ethanol and H2SO4 to the corresponding diethyl ester (IV), which is hydrolyzed selectively with KOH, affording the monoethyl ester (V). Finally, this monoester 5 condensed with N-isoamyl-L-leucinamide (VI).
【1】 Fukushima, K.; et al.; In vivo actions of EST (reort 1) - Absorption and excretion of 14C-EST. Kiso To Rinsho 1986, 20, 4, 319. |
【2】 Castaner, J.; Prous, J.; EST. Drugs Fut 1986, 11, 11, 927. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 23808 | Fumaric acid; (E)-2-butenedioic acid | 110-17-8 | C4H4O4 | 详情 | 详情 |
(II) | 24349 | 2,3-oxiranedicarboxylic acid; Oxirane-2,3-dicarboxylic acid; Epoxysuccinic acid | C4H4O5 | 详情 | 详情 | |
(III) | 24350 | (2S,3S)-2,3-oxiranedicarboxylic acid | C4H4O5 | 详情 | 详情 | |
(IV) | 24351 | diethyl (2S,3S)-2,3-oxiranedicarboxylate | 74243-85-9 | C8H12O5 | 详情 | 详情 |
(V) | 24344 | (2S,3S)-3-(ethoxycarbonyl)-2-oxiranecarboxylic acid | C6H8O5 | 详情 | 详情 | |
(VI) | 24347 | 2-amino-N-isopentyl-4-methylpentanamide | C11H24N2O | 详情 | 详情 |
Extended Information