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【结 构 式】

【分子编号】24350

【品名】(2S,3S)-2,3-oxiranedicarboxylic acid

【CA登记号】

【 分 子 式 】C4H4O5

【 分 子 量 】132.07276

【元素组成】C 36.38% H 3.05% O 60.57%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The synthesis of [14 C]-EST has been described ac cording to the following procedure: The oxidation of fumaric acid (I) with H2O2 gives trans-epoxysuccinic acid (II), which is submitted to optical resolution by means of its salt with L-arginine. The L-trans isomer (III) is esterified with ethanol and H2SO4 to the corresponding diethyl ester (IV), which is hydrolyzed selectively with KOH, affording the monoethyl ester (V). Finally, this monoester 5 condensed with N-isoamyl-L-leucinamide (VI).

1 Fukushima, K.; et al.; In vivo actions of EST (reort 1) - Absorption and excretion of 14C-EST. Kiso To Rinsho 1986, 20, 4, 319.
2 Castaner, J.; Prous, J.; EST. Drugs Fut 1986, 11, 11, 927.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 23808 Fumaric acid; (E)-2-butenedioic acid 110-17-8 C4H4O4 详情 详情
(II) 24349 2,3-oxiranedicarboxylic acid; Oxirane-2,3-dicarboxylic acid; Epoxysuccinic acid C4H4O5 详情 详情
(III) 24350 (2S,3S)-2,3-oxiranedicarboxylic acid C4H4O5 详情 详情
(IV) 24351 diethyl (2S,3S)-2,3-oxiranedicarboxylate 74243-85-9 C8H12O5 详情 详情
(V) 24344 (2S,3S)-3-(ethoxycarbonyl)-2-oxiranecarboxylic acid C6H8O5 详情 详情
(VI) 24347 2-amino-N-isopentyl-4-methylpentanamide C11H24N2O 详情 详情
Extended Information