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【结 构 式】 
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【分子编号】24327 【品名】tropic acid 【CA登记号】529-64-6 |
【 分 子 式 】C9H10O3 【 分 子 量 】166.1766 【元素组成】C 65.05% H 6.07% O 28.88% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)3) The treatment of indomethacin (III) with 1,1'-carbonyldiimidazole (A) at room temperature in dichloromethane affords the imidazolide (IVa), which is reacted with tropic acid (V) under the same mild conditions to afford title compound.
| 【1】 Nemecek, O.; Fisnerova, L.; Grimova, J.; Roubal, Z. (SPOFA - United Pharmaceutical Works); 2-Phenyl-2-carboxyethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate and process for preparation thereof. US 4136194 . |
| 【2】 Fisnerova, L.; Tropesin. Drugs Fut 1986, 11, 9, 779. |
| 【3】 Fisnerova, L.; et al.; Pharmacologically interesting indomethacin derivatives. Cesk Farm 1977, 26, 6, 227-31. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 11353 | 1,1'-Carbonyldiimidazole; Di(1H-imidazol-1-yl)methanone; N,N-Carbonyldiimidazole; 1,1'-Carbonylbis(1H-imidazole) | 530-62-1 | C7H6N4O | 详情 | 详情 |
| (IVa) | 24326 | 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(1H-imidazol-1-yl)-1-ethanone | C22H18ClN3O3 | 详情 | 详情 | |
| (III) | 22930 | 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid | C19H16ClNO4 | 详情 | 详情 | |
| (V) | 24327 | tropic acid | 529-64-6 | C9H10O3 | 详情 | 详情 |
Extended Information