2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(1H-imidazol-1-yl)-1-ethanone -Drug Synthesis Database

【结构式】

【分子编号】24326

【品名】2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(1H-imidazol-1-yl)-1-ethanone

【CA登记号】

【分子式】C₂₂H₁₈ClN₃O₃

【分子量】407.85604

【元素组成】C 64.79% H 4.45% Cl 8.69% N 10.3% O 11.77%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IVa)

3) The treatment of indomethacin (III) with 1,1'-carbonyldiimidazole (A) at room temperature in dichloromethane affords the imidazolide (IVa), which is reacted with tropic acid (V) under the same mild conditions to afford title compound.

参考文献中间体

合成目标

【1】 Nemecek, O.; Fisnerova, L.; Grimova, J.; Roubal, Z. (SPOFA - United Pharmaceutical Works); 2-Phenyl-2-carboxyethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate and process for preparation thereof. US 4136194 .
【2】 Fisnerova, L.; Tropesin. Drugs Fut 1986, 11, 9, 779.
【3】 Fisnerova, L.; et al.; Pharmacologically interesting indomethacin derivatives. Cesk Farm 1977, 26, 6, 227-31.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	11353	1,1'-Carbonyldiimidazole; Di(1H-imidazol-1-yl)methanone; N,N-Carbonyldiimidazole; 1,1'-Carbonylbis(1H-imidazole)	530-62-1	C₇H₆N₄O	详情	详情
(IVa)	24326	2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(1H-imidazol-1-yl)-1-ethanone		C₂₂H₁₈ClN₃O₃	详情	详情
(III)	22930	2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid		C₁₉H₁₆ClNO₄	详情	详情
(V)	24327	tropic acid	529-64-6	C₉H₁₀O₃	详情	详情

Extended Information