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【结 构 式】 
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【分子编号】24256 【品名】3-methyl 5-(3-piperidinyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate 【CA登记号】 |
【 分 子 式 】C21H25N3O6 【 分 子 量 】415.44612 【元素组成】C 60.71% H 6.07% N 10.11% O 23.11% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IX)5) The esterification of (VI) with 3-hydroxypipendine (VIII) as before gives the corresponding ester (IX), which is then benzylated with benzyl chloride (X) by means of triethylamine in refluxing THF.
| 【1】 Muto, K.; Kuroda, T.; Karasawa, A.; Yamada, K.; Nakamizo, N. (Kyowa Hakko Kogyo Co., Ltd.); 1,4-Dihydropyridine derivatives. CA 1246078; EP 0106275; ES 526441 . |
| 【2】 Prous, J.; Castaner, J.; KW-3049. Drugs Fut 1986, 11, 11, 936. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 13950 | 5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid | C16H16N2O6 | 详情 | 详情 | |
| (VIII) | 24255 | 3-piperidinol | 6859-99-0 | C5H11NO | 详情 | 详情 |
| (IX) | 24256 | 3-methyl 5-(3-piperidinyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate | C21H25N3O6 | 详情 | 详情 | |
| (X) | 19171 | 1-(Chloromethyl)benzene; Benzyl chloride | 100-44-7 | C7H7Cl | 详情 | 详情 |
Extended Information