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【结 构 式】

【分子编号】24073

【品名】8-thiochromanol

【CA登记号】

【 分 子 式 】C9H10OS

【 分 子 量 】166.2438

【元素组成】C 65.02% H 6.06% O 9.62% S 19.29%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The cyclization of 3-(2-methoxyphenylthio)propionic acid (II) with PPA yields 8 methoxythiochroman-4-one (III). Thiochromanone (III) is then reduced to 8-hydroxythiochromane (IV) by the Wolff-Kishner reduction method. Demethylation is almost complete during this reduction. The 8-hydroxythiochromane (IV), treated with epichlorohydrin, yields the corresponding epoxide (V), which when treated with excess tert-butylamine yields tertatolol base.

1 Leclerc, G.; Tertatolol hydrochloride. Drugs Fut 1986, 11, 2, 131.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 24070 2-methoxyphenylhydrosulfide 7217-59-6 C7H8OS 详情 详情
(II) 24071 3-[(2-methoxyphenyl)sulfanyl]propionic acid C10H12O3S 详情 详情
(III) 24072 8-methoxy-2,3-dihydro-4H-thiochromen-4-one C10H10O2S 详情 详情
(IV) 24073 8-thiochromanol C9H10OS 详情 详情
(V) 24074 2-[(3,4-dihydro-2H-thiochromen-8-yloxy)methyl]oxirane C12H14O2S 详情 详情
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