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【结 构 式】 
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【药物名称】Tertatolol hydrochloride, SE-2395, Prenalex, Artexal, Artex 【化学名称】(±)-1-[(3,4-Dihydro-2H-1-benzothiopyran-8-yl)oxy]-3-[(1,1-dimethylethyl)amino]-2-propanol hydrochloride 【CA登记号】33580-30-2, 34784-64-0 (free base) 【 分 子 式 】C16H26ClNO2S 【 分 子 量 】331.90812 |
【开发单位】Servier (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Hypertension, Treatment of, beta-Adrenoceptor Antagonists |
合成路线1
The cyclization of 3-(2-methoxyphenylthio)propionic acid (II) with PPA yields 8 methoxythiochroman-4-one (III). Thiochromanone (III) is then reduced to 8-hydroxythiochromane (IV) by the Wolff-Kishner reduction method. Demethylation is almost complete during this reduction. The 8-hydroxythiochromane (IV), treated with epichlorohydrin, yields the corresponding epoxide (V), which when treated with excess tert-butylamine yields tertatolol base.
| 【1】 Leclerc, G.; Tertatolol hydrochloride. Drugs Fut 1986, 11, 2, 131. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24070 | 2-methoxyphenylhydrosulfide | 7217-59-6 | C7H8OS | 详情 | 详情 |
| (II) | 24071 | 3-[(2-methoxyphenyl)sulfanyl]propionic acid | C10H12O3S | 详情 | 详情 | |
| (III) | 24072 | 8-methoxy-2,3-dihydro-4H-thiochromen-4-one | C10H10O2S | 详情 | 详情 | |
| (IV) | 24073 | 8-thiochromanol | C9H10OS | 详情 | 详情 | |
| (V) | 24074 | 2-[(3,4-dihydro-2H-thiochromen-8-yloxy)methyl]oxirane | C12H14O2S | 详情 | 详情 |