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【结 构 式】

【分子编号】23922

【品名】7-(2-oxiranylmethoxy)-2-phenyl-4H-chromen-4-one

【CA登记号】

【 分 子 式 】C18H14O4

【 分 子 量 】294.30676

【元素组成】C 73.46% H 4.79% O 21.75%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The condensation of epichlorohydrin (I) with 7-hydroxyflavone (II) by means of NaOH in ethanol - water gives 7-(2,3-epoxypropoxy)fIavone (III), which is then treated with propylamine (IV) in methanol, and neutralized with maleic acid.

1 Wu, E.S.-C. (Pennwalt Corp.); Antihypertensive agents. EP 0064165; US 4501755 .
2 Castaner, J.; Prous, J.; Flavodilol maleate. Drugs Fut 1986, 11, 10, 837.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
37495 Maleic acid; (Z)-2-Butenedioic acid 110-16-7 C4H4O4 详情 详情
(I) 10146 Epichlorohydrin; 2-(Chloromethyl)oxirane 106-89-8 C3H5ClO 详情 详情
(II) 23921 7-hydroxy-2-phenyl-4H-chromen-4-one 6665-86-7 C15H10O3 详情 详情
(III) 23922 7-(2-oxiranylmethoxy)-2-phenyl-4H-chromen-4-one C18H14O4 详情 详情
(IV) 23923 1-propanamine 107-10-8 C3H9N 详情 详情
Extended Information