Flavodilol maleate, PR-87730L, -Drug Synthesis Database

【结构式】

【药物名称】Flavodilol maleate, PR-87730L

【化学名称】(±)-7-[2-Hydroxy-3-(propylamino)propoxy]-2-phenyl-4H-1-benzopyran-4-one (Z)-2-butenedioate (1:1) (salt)
　　　　　　(±)-7-(2-Hydroxy-3-(propylamino)propoxy]flavone maleate (1:1) (salt)

【CA登记号】79619-32-2, 79619-31-1 (free base)

【分子式】C₂₅H₂₇NO₈

【分子量】469.49584

【开发单位】Pennwalt (Originator)

【药理作用】CARDIOVASCULAR DRUGS, Hypertension, Treatment of

合成路线1

The condensation of epichlorohydrin (I) with 7-hydroxyflavone (II) by means of NaOH in ethanol - water gives 7-(2,3-epoxypropoxy)fIavone (III), which is then treated with propylamine (IV) in methanol, and neutralized with maleic acid.

参考文献中间体

【1】 Wu, E.S.-C. (Pennwalt Corp.); Antihypertensive agents. EP 0064165; US 4501755 .
【2】 Castaner, J.; Prous, J.; Flavodilol maleate. Drugs Fut 1986, 11, 10, 837.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	37495	Maleic acid; (Z)-2-Butenedioic acid	110-16-7	C₄H₄O₄	详情	详情
(I)	10146	Epichlorohydrin; 2-(Chloromethyl)oxirane	106-89-8	C₃H₅ClO	详情	详情
(II)	23921	7-hydroxy-2-phenyl-4H-chromen-4-one	6665-86-7	C₁₅H₁₀O₃	详情	详情
(III)	23922	7-(2-oxiranylmethoxy)-2-phenyl-4H-chromen-4-one		C₁₈H₁₄O₄	详情	详情
(IV)	23923	1-propanamine	107-10-8	C₃H₉N	详情	详情

Extended Information