6-chloro-8-methyl[1,2,4]triazolo[4,3-b]pyridazine -Drug Synthesis Database

【结构式】

【分子编号】23911

【品名】6-chloro-8-methyl[1,2,4]triazolo[4,3-b]pyridazine

【CA登记号】

【分子式】C₆H₅ClN₄

【分子量】168.58536

【元素组成】C 42.75% H 2.99% Cl 21.03% N 33.23%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

1) The cyclization of 6-chloro-3-hydrazino-4-methylpyridazine (I) with refluxing formic acid gives 6-chloro-8-methyl-1,2,4-triazolo[4,3-b]pyridazine (II), which is then condensed with piperidine (III) at reflux temperature.

参考文献中间体

合成目标

【1】 Peet, N.P.; Sunder, S. (Aventis Pharmaceuticals, Inc.); 3,6,7,8-Substituted-s-triazolo[4,3-b]-pyridazines, their preparations and compositions comprising them. EP 0029130; GB 2061275; JP 56079690 .
【2】 Lewis, J.; Shea, P.J. (Aventis Pharmaceuticals, Inc.); Triazolopyridazines used to alleviate bronchial spasms. US 4136182 .
【3】 Castaner, J.; Prous, J.; Zindotrine. Drugs Fut 1986, 11, 10, 865.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23910	6-chloro-3-hydrazino-4-methylpyridazine		C₅H₇ClN₄	详情	详情
(II)	23911	6-chloro-8-methyl[1,2,4]triazolo[4,3-b]pyridazine		C₆H₅ClN₄	详情	详情
(III)	10158	Piperidine	110-89-4	C₅H₁₁N	详情	详情

Extended Information