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【结 构 式】

【分子编号】23910

【品名】6-chloro-3-hydrazino-4-methylpyridazine

【CA登记号】

【 分 子 式 】C5H7ClN4

【 分 子 量 】158.59024

【元素组成】C 37.87% H 4.45% Cl 22.35% N 35.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

1) The cyclization of 6-chloro-3-hydrazino-4-methylpyridazine (I) with refluxing formic acid gives 6-chloro-8-methyl-1,2,4-triazolo[4,3-b]pyridazine (II), which is then condensed with piperidine (III) at reflux temperature.

1 Peet, N.P.; Sunder, S. (Aventis Pharmaceuticals, Inc.); 3,6,7,8-Substituted-s-triazolo[4,3-b]-pyridazines, their preparations and compositions comprising them. EP 0029130; GB 2061275; JP 56079690 .
2 Lewis, J.; Shea, P.J. (Aventis Pharmaceuticals, Inc.); Triazolopyridazines used to alleviate bronchial spasms. US 4136182 .
3 Castaner, J.; Prous, J.; Zindotrine. Drugs Fut 1986, 11, 10, 865.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 23910 6-chloro-3-hydrazino-4-methylpyridazine C5H7ClN4 详情 详情
(II) 23911 6-chloro-8-methyl[1,2,4]triazolo[4,3-b]pyridazine C6H5ClN4 详情 详情
(III) 10158 Piperidine 110-89-4 C5H11N 详情 详情
Extended Information