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【结 构 式】 
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【分子编号】23435 【品名】4-[(1-pyrrolidinylsulfonyl)methyl]phenylamine; 4-[(1-pyrrolidinylsulfonyl)methyl]aniline 【CA登记号】 |
【 分 子 式 】C11H16N2O2S 【 分 子 量 】240.32632 【元素组成】C 54.98% H 6.71% N 11.66% O 13.31% S 13.34% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IX)4) The intermediate 4-(1-pyrrolidinylsulfonylmethyl)phenylhydrazine (III) can be obtained as follows: The condensation of pyrrolidine (VI) with 1-(4-nitrobenzylsulfonyl)chloride (VII) in dichloromethane gives the expected sulfonamide (VIII), which is reduced with H2 over RaNi in DMF, yielding 4-(1-pyrrolidinylsulfonylmethyl)aniline (IX). The diazotation of (IX) with NaNO2/HCl affords the corresponding diazo compound (X), which is finally reduced to the target intermediate (III) with SnCl2/HCl.
| 【1】 Fernandez-Forner, D.; New aniline derivatives as key intermediates in th. Res Disclosure 1998, 412, 1088. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 23429 | 1-[(4-hydrazinobenzyl)sulfonyl]pyrrolidine | C11H17N3O2S | 详情 | 详情 | |
| (VI) | 11376 | Pyrrolidine | 123-75-1 | C4H9N | 详情 | 详情 |
| (VII) | 23433 | (4-nitrophenyl)methanesulfonyl chloride | C7H6ClNO4S | 详情 | 详情 | |
| (VIII) | 23434 | 1-[(4-nitrobenzyl)sulfonyl]pyrrolidine | C11H14N2O4S | 详情 | 详情 | |
| (IX) | 23435 | 4-[(1-pyrrolidinylsulfonyl)methyl]phenylamine; 4-[(1-pyrrolidinylsulfonyl)methyl]aniline | C11H16N2O2S | 详情 | 详情 | |
| (X) | 23436 | 4-[(1-pyrrolidinylsulfonyl)methyl]benzenediazonium | C11H14N3O2S | 详情 | 详情 |
Extended Information