1-[(4-nitrobenzyl)sulfonyl]pyrrolidine -Drug Synthesis Database

【结构式】

【分子编号】23434

【品名】1-[(4-nitrobenzyl)sulfonyl]pyrrolidine

【CA登记号】

【分子式】C₁₁H₁₄N₂O₄S

【分子量】270.30924

【元素组成】C 48.88% H 5.22% N 10.36% O 23.68% S 11.86%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIII)

4) The intermediate 4-(1-pyrrolidinylsulfonylmethyl)phenylhydrazine (III) can be obtained as follows: The condensation of pyrrolidine (VI) with 1-(4-nitrobenzylsulfonyl)chloride (VII) in dichloromethane gives the expected sulfonamide (VIII), which is reduced with H2 over RaNi in DMF, yielding 4-(1-pyrrolidinylsulfonylmethyl)aniline (IX). The diazotation of (IX) with NaNO2/HCl affords the corresponding diazo compound (X), which is finally reduced to the target intermediate (III) with SnCl2/HCl.

参考文献中间体

合成目标

【1】 Fernandez-Forner, D.; New aniline derivatives as key intermediates in th. Res Disclosure 1998, 412, 1088.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(III)	23429	1-[(4-hydrazinobenzyl)sulfonyl]pyrrolidine		C₁₁H₁₇N₃O₂S	详情	详情
(VI)	11376	Pyrrolidine	123-75-1	C₄H₉N	详情	详情
(VII)	23433	(4-nitrophenyl)methanesulfonyl chloride		C₇H₆ClNO₄S	详情	详情
(VIII)	23434	1-[(4-nitrobenzyl)sulfonyl]pyrrolidine		C₁₁H₁₄N₂O₄S	详情	详情
(IX)	23435	4-[(1-pyrrolidinylsulfonyl)methyl]phenylamine; 4-[(1-pyrrolidinylsulfonyl)methyl]aniline		C₁₁H₁₆N₂O₂S	详情	详情
(X)	23436	4-[(1-pyrrolidinylsulfonyl)methyl]benzenediazonium		C₁₁H₁₄N₃O₂S	详情	详情

Extended Information