4-[5-(1H-imidazol-1-yl)-2-methylbenzoyl]-3,5-dimethylbenzoic acid -Drug Synthesis Database

【结构式】

【分子编号】23249

【品名】4-[5-(1H-imidazol-1-yl)-2-methylbenzoyl]-3,5-dimethylbenzoic acid

【CA登记号】

【分子式】C₂₀H₁₈N₂O₃

【分子量】334.3746

【元素组成】C 71.84% H 5.43% N 8.38% O 14.35%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of 4-(5-iodo-2-methylbenzoyl)-3,5-dimethylbenzoic acid (I) with imidazole (II) by means of K2CO3, KF and Cu in DMF at 135 C gives 4-[5-(1-imidazolyl)-2-methylbenzoyl]-3,5-dimethylbenzoic acid (III), which is then reduced with NaBH4 in hot aqueous NaOH.

参考文献中间体

合成目标

【1】 Mineo, T. (Welfide Corporation); Imidazole derivative. JP 1986277670 .
【2】 Prous, J.; Castaner, J.; Y-20811. Drugs Fut 1988, 13, 11, 970.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23247	4-(5-iodo-2-methylbenzoyl)-3,5-dimethylbenzoic acid		C₁₇H₁₅IO₃	详情	详情
(II)	10255	Imidazole; 1H-Imidazole	288-32-4	C₃H₄N₂	详情	详情
(III)	23249	4-[5-(1H-imidazol-1-yl)-2-methylbenzoyl]-3,5-dimethylbenzoic acid		C₂₀H₁₈N₂O₃	详情	详情

Extended Information