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【结 构 式】 
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【药物名称】Y-20811 【化学名称】4-[alpha-Hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid sodium salt dihydrate 【CA登记号】104363-98-6 (anhydrous) 【 分 子 式 】C20H23N2NaO5 【 分 子 量 】394.40651 |
【开发单位】Mitsubishi Pharma (Originator), Mitsubishi Pharma (Licensee) 【药理作用】Antiallergy/Antiasthmatic Drugs, Anticoagulants, Antiplatelet Therapy, Asthma Therapy, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, RESPIRATORY DRUGS, Thromboxane Synthase Inhibitors |
合成路线1
The reaction of 4-(5-iodo-2-methylbenzoyl)-3,5-dimethylbenzoic acid (I) with imidazole (II) by means of K2CO3, KF and Cu in DMF at 135 C gives 4-[5-(1-imidazolyl)-2-methylbenzoyl]-3,5-dimethylbenzoic acid (III), which is then reduced with NaBH4 in hot aqueous NaOH.
| 【1】 Mineo, T. (Welfide Corporation); Imidazole derivative. JP 1986277670 . |
| 【2】 Prous, J.; Castaner, J.; Y-20811. Drugs Fut 1988, 13, 11, 970. |
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