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【结 构 式】

【分子编号】23054

【品名】3-cyclohexylpropanoyl chloride

【CA登记号】39098-75-4

【 分 子 式 】C9H15ClO

【 分 子 量 】174.6702

【元素组成】C 61.89% H 8.66% Cl 20.3% O 9.16%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The synthesis of D-16120 can be achieved by several methods: 1) Aminolysis of 3-cyclohexylpropionyl chloride (I) with 2-ethoxyphenylpiperazine (II) in the presence of triethylamine yields D-16120. 2) Reaction of ethyl 3-cyclohexylpropionate (III) with 2-ethoxyphenylpiperazine (IV) also gives D-16120.

1 Rocco, F.; Caputo, O.; Grosa, G.; Metabolism of 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl)piperazine (D-16120) by rat liver microsomes. Eur J Drug Metab Pharmacokinet 1994, 19, 4, 303.
2 Engel, J.; Jakovlev, V.; Oepen, G.; Thiemer, K. (Degussa-Huls AG); 1-Cycloalkyl-3-acylpiperazine derivs.. EP 0120465; US 4547505 .
3 Oepen, G.; Nickel, B.; Molliere, M.; Engel, J.; D-16120. Drugs Fut 1987, 12, 3, 209.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 23054 3-cyclohexylpropanoyl chloride 39098-75-4 C9H15ClO 详情 详情
(II) 23055 ethyl 2-(1-piperazinyl)phenyl ether; 1-(2-ethoxyphenyl)piperazine C12H18N2O 详情 详情
(III) 23056 ethyl 3-cyclohexylpropanoate 10094-36-7 C11H20O2 详情 详情
Extended Information