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【结 构 式】 
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【药物名称】D-16120 【化学名称】1-(2-Ethoxyphenyl)-4-(3-cyclohexylpropionyl)piperazine hydrochloride 【CA登记号】96222-01-4 【 分 子 式 】C21H33ClN2O2 【 分 子 量 】380.96236 |
【开发单位】Degussa (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Non-Opioid Analgesics |
合成路线1
The synthesis of D-16120 can be achieved by several methods: 1) Aminolysis of 3-cyclohexylpropionyl chloride (I) with 2-ethoxyphenylpiperazine (II) in the presence of triethylamine yields D-16120. 2) Reaction of ethyl 3-cyclohexylpropionate (III) with 2-ethoxyphenylpiperazine (IV) also gives D-16120.
| 【1】 Rocco, F.; Caputo, O.; Grosa, G.; Metabolism of 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl)piperazine (D-16120) by rat liver microsomes. Eur J Drug Metab Pharmacokinet 1994, 19, 4, 303. |
| 【2】 Engel, J.; Jakovlev, V.; Oepen, G.; Thiemer, K. (Degussa-Huls AG); 1-Cycloalkyl-3-acylpiperazine derivs.. EP 0120465; US 4547505 . |
| 【3】 Oepen, G.; Nickel, B.; Molliere, M.; Engel, J.; D-16120. Drugs Fut 1987, 12, 3, 209. |
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