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【结 构 式】 
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【分子编号】22893 【品名】2,2-diethoxyacetic acid 【CA登记号】 |
【 分 子 式 】C6H12O4 【 分 子 量 】148.15888 【元素组成】C 48.64% H 8.16% O 43.2% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)2) By an acid catalyzed condensation of 7-guanidinoheptanamide (IX) with an equivalent amount of glyoxylspermidine (X) in the presence of glutaric acid at 60 C for 8 h. Purification of the reaction mixture gives DSG in 39% yield.
| 【1】 Umezawa, H.; Kuroda, H.; Nakamura, T.; Umeda, Y.; Iinuma, H.; Moriguchi, M.; Takeuchi, T.; Synthesis and antitumor activity of spergualin analogues. I. Chemical modification of 7-guanidino-3-hydroxyacyl moiety. J Antibiot 1985, 38, 7, 886-898. |
| 【2】 Kondo, S.; Ikeda, Y.; Ikeda, D.; Iwasawa, H.; Umezawa, H.; Iinuma, H.; Umeda, Y.; The total synthesis of spergualin, an antitumor antibiotic. J Antibiot 1981, 34, 12, 1625-1627. |
| 【3】 Umezawa, H.; Takeuchi, T.; Kondo, S. (Microbial Chemistry Research Foundation); (-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same. US 4525299 . |
| 【4】 Fujii, A.; Iinuma, H.; Ikeda, D.; Kondo, S.; Nakamura, T.; Takeuchi, T.; Umezawa, H. (Microbial Chemistry Research Foundation); N-[4-(3-Aminopropyl)-aminobutyl]-2-(omega-guanidino-fatty-acid-amido)-2-substd.-ethanamide and salt thereof. BE 0894651; US 4518532; US 4658058 . |
| 【5】 Inokai, K.; Fujii, A.; Takeuchi, T.; Umeda, Y.; Moriguchi, M.; Nakamura, T.; Umezawa, H. (Nippon Kayaku Co., Ltd.; Takara Shuzo Co., Ltd.); Spegualin-related nitrile cpds. and their preparation method. JP 1985178853 . |
| 【6】 Suzuki, M.; Nishizawa, R.; Takei, M.; Yoshida, M. (Nippon Kayaku Co., Ltd.); Purification method of spergualin or its derivs.. JP 1984029652 . |
| 【7】 Nakamura, T.; Moriguchi, M.; Inokai, K.; Umeda, Y.; Umezawa, H.; Takeuchi, T.; Fujii, A. (Nippon Kayaku Co., Ltd.; Takara Shuzo Co., Ltd.); Adduct of omega-guanidino fatty acid amide and glyoxylic acid, and its preparation method. JP 1985178852 . |
| 【8】 Takeuchi, T.; Umezawa, H.; Kondo, S.; Nakamura, T.; Iinuma, H.; Ikeda, T.; Fujii, A. (Microbial Chemistry Research Foundation); (S)-7-Guanidino-3-hydroxyheptanamide and its synthesis method. JP 1982188562 . |
| 【9】 Ikeda, D.; Nakamura, T.; Fujii, A.; Umezawa, H.; Kondo, S.; Iinuma, H.; Takeuchi, T. (Microbial Chemistry Research Foundation); N-[4-(3-Aminopropyl)aminobutyl]-2,2-dihydroxyethanamide and process for its synthesis. DE 3217693; GB 2100253 . |
| 【10】 Takeuchi, T.; Fujii, A.; Nakamura, T.; Umeda, Y.; Moriguchi, M.; Umezawa, H. (Nippon Kayaku Co., Ltd.; Takara Shuzo Co., Ltd.); Method for producing glyoxylspermidine and the use thereof for the production of 15-deoxy spergualin-related cpds.. DE 3506330; US 4603015 . |
| 【11】 Cheng, C.C.; Zee-Cheng, R.K.-Y.; Deoxyspergualin. Drugs Fut 1987, 12, 2, 113. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 10274 | 7-[[Amino(imino)methyl]amino]heptanoic acid | C8H17N3O2 | 详情 | 详情 | |
| (VI) | 10273 | 7-Aminoheptanoic acid | 929-17-9 | C7H15NO2 | 详情 | 详情 |
| (VII) | 22892 | N-(4-aminobutyl)-N-(3-aminopropyl)amine; N(1)-(3-aminopropyl)-1,4-butanediamine | 124-20-9 | C7H19N3 | 详情 | 详情 |
| (VIII) | 22893 | 2,2-diethoxyacetic acid | C6H12O4 | 详情 | 详情 | |
| (IX) | 10270 | 7-[[Amino(imino)methyl]amino]heptanamide | C8H18N4O | 详情 | 详情 | |
| (X) | 10271 | N-[4-[(3-Aminopropyl)amino]butyl]-2,2-dihydroxyacetamide | C9H21N3O3 | 详情 | 详情 |
Extended Information