【结 构 式】 |
【分子编号】22709 【品名】ethyl 4-hydroxy-1-piperidinecarboxylate 【CA登记号】 |
【 分 子 式 】C8H15NO3 【 分 子 量 】173.21204 【元素组成】C 55.47% H 8.73% N 8.09% O 27.71% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(VI)Synthesis of intermediate (X): 4-Hydroxypiperidine (V) is protected with ethyl chloroformate to give (VI), which is then condensed with bromodiphenylmethane in the presence of sodium carbonate yielding (VII). AIkali hydrolysis of (VII) gives (VIII), which is then treated with N-(2-bromoethyl)phthalimide to yield (IX). (IX) is then deprotected by a treatment of 80% hydrazine hydrate, producing (X).
【1】 Tasaka, K.; TMK-688. Drugs Fut 1988, 13, 12, 1056. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
37025 | 2-(2-bromoethyl)-1H-isoindole-1,3(2H)-dione | 574-98-1 | C10H8BrNO2 | 详情 | 详情 | |
(IIb) | 12079 | Bromodiphenylmethane; 1-[Bromo(phenyl)methyl]benzene; Benzhydrylbromide | 776-74-9 | C13H11Br | 详情 | 详情 |
(V) | 12076 | 4-Piperidinol; 4-Hydroxypiperidine | 5382-16-1 | C5H11NO | 详情 | 详情 |
(VI) | 22709 | ethyl 4-hydroxy-1-piperidinecarboxylate | C8H15NO3 | 详情 | 详情 | |
(VII) | 12080 | ethyl 4-(benzhydryloxy)tetrahydro-1(2H)-pyridinecarboxylate | C21H25NO3 | 详情 | 详情 | |
(VIII) | 12081 | 4-(Benzhydryloxy)piperidine; Benzhydryl 4-piperidinyl ether | C18H21NO | 详情 | 详情 | |
(IX) | 22713 | 2-[2-[4-(benzhydryloxy)-1-piperidinyl]ethyl]-1H-isoindole-1,3(2H)-dione | C28H28N2O3 | 详情 | 详情 | |
(X) | 22707 | 2-[4-(benzhydryloxy)-1-piperidinyl]ethylamine; 2-[4-(benzhydryloxy)-1-piperidinyl]-1-ethanamine | C20H26N2O | 详情 | 详情 |
Extended Information