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【结 构 式】 
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【分子编号】23538 【品名】1-acetyl-2-imidazolidinone 【CA登记号】 |
【 分 子 式 】C5H8N2O2 【 分 子 量 】128.1308 【元素组成】C 46.87% H 6.29% N 21.86% O 24.97% |
合成路线1
该中间体在本合成路线中的序号：(II)The condensation of 5-amino 2 methyl 4,6-dichloropyrimidine (I) with 1-acetyl-2-imidazolin-2-one (II) by means of POCl3 at 50 C gives 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-ylamino)pyrimidine (III), which is then methoxylated and desacetylated by treatment with sodium methoxide in refluxing methanol.
| 【1】 Mutsumi, M. (Nippon Chemiphar Co., Ltd.); Novel remedy for peptic ulcer. JP 1982075920 . |
| 【2】 Mannhold, R.; Moxonidine hydrochloride. Drugs Fut 1987, 12, 6, 553. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23537 | 4,6-dichloro-2-methyl-5-pyrimidinamine; 4,6-dichloro-2-methyl-5-pyrimidinylamine | C5H5Cl2N3 | 详情 | 详情 | |
| (II) | 23538 | 1-acetyl-2-imidazolidinone | C5H8N2O2 | 详情 | 详情 | |
| (III) | 23539 | 1-[2-[(4,6-dichloro-2-methyl-5-pyrimidinyl)amino]-4,5-dihydro-1H-imidazol-1-yl]-1-ethanone | C10H11Cl2N5O | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(II)By condensation of 4-chloro-2-aminoisoindoline (I) with 1-acetylimidazolidin-2-one (II) by means of POCl3 at 100 C, followed by hydrolysis of the acetyl group with hot ethanol.
| 【1】 Cohnen, E. (Beiersdorf-Lilly GmbH); Hypotensive 2-heterocycloaminoimidazolines. DE 2816627; DE 2905501; FR 2423491; GB 2021100; JP 79151990; US 4221798 . |
| 【2】 Castaner, J.; Serradell, M.N.; BDF-6143. Drugs Fut 1984, 9, 2, 100. |
合成路线3
该中间体在本合成路线中的序号：(VII)By reacting 1-acetyl-2-imidazolidinone (VII) with 4-aminoindan (I) and POCl3 at 50 C 1-acetylindanazolidine (VIII) is synthesized, which gives indanazoline by hydrolysis
| 【1】 Kirchhoff, T.; Kauff, N.D.; Mitra, N.; et al.; BRCA mutations and risk of prostate cancer in ashkenazi jews. Arzneim-Forsch Drug Res 1980, 30, 9, 1733. |
| 【2】 May, H.J.; Koening, H. (BASF AG); DE 2652004; FR 2370736; NL 7712149 . |
| 【3】 Unterhalt, B.; Indanazoline Hydrochloride. Drugs Fut 1981, 6, 7, 417. |