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【结 构 式】 
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【分子编号】22133 【品名】2-[[2-[bis(carboxymethyl)amino]-1-methylethyl](carboxymethyl)amino]acetic acid 【CA登记号】 |
【 分 子 式 】C11H18N2O8 【 分 子 量 】306.2726 【元素组成】C 43.14% H 5.92% N 9.15% O 41.79% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Condensation of (rac)-propylene-1,2-diaminetetraacetic acid (I) with formamide gives (rac)-1,2-bis(3,5-dioxopiperazin-1-yl)propane (II). The latter compound is heated with morpholine, and then treated with aqueous formaldehyde. Probimane separates on cooling of the reaction mixture.
| 【1】 Ren, Y.-F. (Zenyaku Kogyo Co., Ltd.); Bis-dioxopiperazine derivs., process for their preparation, antitumor agents comprising them and compsns. containing them. EP 0125475; JP 1984190976; JP 1985025975; JP 1985069070; US 4737497 . |
| 【2】 Ruyun, J.; Probimane. Drugs Fut 1988, 13, 5, 418. |
Extended Information