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【结 构 式】 
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【药物名称】Probimane, AT-2153, MST-02 【化学名称】(±)-(4,4'-Propane-1,2-diyl)bis[1-(morpholin-4-ylmethyl)piperazine-2,6-dione] 【CA登记号】95604-83-4 【 分 子 式 】C21H34N6O6 【 分 子 量 】466.54173 |
【开发单位】Shanghai Institute Materia Medica (Originator), Zenyaku Kogyo (Originator) 【药理作用】ONCOLYTIC DRUGS |
合成路线1
Condensation of (rac)-propylene-1,2-diaminetetraacetic acid (I) with formamide gives (rac)-1,2-bis(3,5-dioxopiperazin-1-yl)propane (II). The latter compound is heated with morpholine, and then treated with aqueous formaldehyde. Probimane separates on cooling of the reaction mixture.
| 【1】 Ren, Y.-F. (Zenyaku Kogyo Co., Ltd.); Bis-dioxopiperazine derivs., process for their preparation, antitumor agents comprising them and compsns. containing them. EP 0125475; JP 1984190976; JP 1985025975; JP 1985069070; US 4737497 . |
| 【2】 Ruyun, J.; Probimane. Drugs Fut 1988, 13, 5, 418. |
Extended Information