【结 构 式】 |
【分子编号】21944 【品名】ethyl 4-[2-[(1H-indol-5-ylcarbonyl)amino]phenoxy]butanoate 【CA登记号】 |
【 分 子 式 】C21H22N2O4 【 分 子 量 】366.41676 【元素组成】C 68.84% H 6.05% N 7.65% O 17.47% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XI)Imidazole-5-carboxylic acid (VIII) was condensed with the aniline (VII) using 2-chloro-1-methylpyridinium iodide (CMP) and Bu3N to afford amide (XI). Subsequent alkylation of the indole nitrogen atom of (XI) with 4,4'-dipropylbenzhydryl bromide (IX) in the presence of t-BuOK provided the target compound.
【1】 Takami, H.; Kishibayashi, N.; Ishii, A.; Kumazawa, T.; Indole and benzimidazole derivatives as steroid 5alpha-reductase inhibitors in the rat prostate. Bioorg Med Chem 1998, 6, 12, 2441. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(VII) | 21940 | ethyl 4-(2-aminophenoxy)butanoate | C12H17NO3 | 详情 | 详情 | |
(VIII) | 21941 | 1H-benzimidazole-5-carboxylic acid | 15788-16-6 | C8H6N2O2 | 详情 | 详情 |
(IX) | 21942 | 1-[bromo(4-propylphenyl)methyl]-4-propylbenzene | C19H23Br | 详情 | 详情 | |
(XI) | 21944 | ethyl 4-[2-[(1H-indol-5-ylcarbonyl)amino]phenoxy]butanoate | C21H22N2O4 | 详情 | 详情 |
Extended Information