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【结 构 式】 
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【药物名称】 【化学名称】4-[2-[1-[bis(4-Propylphenyl)methyl]-1H-benzimidazol-5-ylcarboxamido]phenoxy]butyric acid ethyl ester 【CA登记号】 【 分 子 式 】C39H43N3O4 【 分 子 量 】617.79526 |
【开发单位】Kyowa Hakko (Originator) 【药理作用】Benign Prostatic Hyperplasia Therapy, RENAL-UROLOGIC DRUGS, Steroid 5alpha-Reductase Inhibitors |
合成路线1
The condensation of methyl 4-chloro-3-nitrobenzoate (I) with dipropylbenzhydryl amine (II), followed by reduction of the nitro group of the resulting (III) with H2 in the presence of PtO2 yielded diamine (IV). Treatment of (IV) with triethyl orthoformate and formic acid at 120 C produced the benzimidazole (V), which was hydrolyzed with NaOH to the benzimidazolecarboxylic (VI). Finally, acid (VI) was condensed with aniline (VII) using 2-chloro-1-methylpyridinium iodide (CMP) and Bu3N to furnish the target amide.
| 【1】 Takami, H.; Kishibayashi, N.; Ishii, A.; Kumazawa, T.; Indole and benzimidazole derivatives as steroid 5alpha-reductase inhibitors in the rat prostate. Bioorg Med Chem 1998, 6, 12, 2441. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21934 | methyl 4-chloro-3-nitrobenzoate | 14719-83-6 | C8H6ClNO4 | 详情 | 详情 |
| (II) | 21935 | bis(4-propylphenyl)methanamine; bis(4-propylphenyl)methylamine | C19H25N | 详情 | 详情 | |
| (III) | 21936 | N-[4-(methoxymethyl)-2-nitrophenyl]-N-[phenyl(4-propylphenyl)methyl]amine; 4-(methoxymethyl)-2-nitro-N-[phenyl(4-propylphenyl)methyl]aniline | C24H26N2O3 | 详情 | 详情 | |
| (IV) | 21937 | methyl 3-amino-4-[[bis(4-propylphenyl)methyl]amino]benzoate | C27H32N2O2 | 详情 | 详情 | |
| (V) | 21938 | methyl 1-[bis(4-propylphenyl)methyl]-1H-benzimidazole-5-carboxylate | C28H30N2O2 | 详情 | 详情 | |
| (VI) | 21939 | 1-[bis(4-propylphenyl)methyl]-1H-benzimidazole-5-carboxylic acid | C27H28N2O2 | 详情 | 详情 | |
| (VII) | 21940 | ethyl 4-(2-aminophenoxy)butanoate | C12H17NO3 | 详情 | 详情 |
合成路线2
The intermediate benzimidazolecarboxylic acid (VI) cal also be obtained as follows: Alkylation of benzimidazole-5-carboxylic acid (VIII) with 4,4'-dipropylbenzhydryl bromide (XI) afforded a mixture of alkylated benzimidazoles (VI) and (X), which were separated by column chromatography.
| 【1】 Takami, H.; Kishibayashi, N.; Ishii, A.; Kumazawa, T.; Indole and benzimidazole derivatives as steroid 5alpha-reductase inhibitors in the rat prostate. Bioorg Med Chem 1998, 6, 12, 2441. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 21939 | 1-[bis(4-propylphenyl)methyl]-1H-benzimidazole-5-carboxylic acid | C27H28N2O2 | 详情 | 详情 | |
| (VIII) | 21941 | 1H-benzimidazole-5-carboxylic acid | 15788-16-6 | C8H6N2O2 | 详情 | 详情 |
| (IX) | 21942 | 1-[bromo(4-propylphenyl)methyl]-4-propylbenzene | C19H23Br | 详情 | 详情 | |
| (X) | 21943 | 1-[bis(4-propylphenyl)methyl]-1H-benzimidazole-6-carboxylic acid | C27H28N2O2 | 详情 | 详情 |
合成路线3
Imidazole-5-carboxylic acid (VIII) was condensed with the aniline (VII) using 2-chloro-1-methylpyridinium iodide (CMP) and Bu3N to afford amide (XI). Subsequent alkylation of the indole nitrogen atom of (XI) with 4,4'-dipropylbenzhydryl bromide (IX) in the presence of t-BuOK provided the target compound.
| 【1】 Takami, H.; Kishibayashi, N.; Ishii, A.; Kumazawa, T.; Indole and benzimidazole derivatives as steroid 5alpha-reductase inhibitors in the rat prostate. Bioorg Med Chem 1998, 6, 12, 2441. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 21940 | ethyl 4-(2-aminophenoxy)butanoate | C12H17NO3 | 详情 | 详情 | |
| (VIII) | 21941 | 1H-benzimidazole-5-carboxylic acid | 15788-16-6 | C8H6N2O2 | 详情 | 详情 |
| (IX) | 21942 | 1-[bromo(4-propylphenyl)methyl]-4-propylbenzene | C19H23Br | 详情 | 详情 | |
| (XI) | 21944 | ethyl 4-[2-[(1H-indol-5-ylcarbonyl)amino]phenoxy]butanoate | C21H22N2O4 | 详情 | 详情 |