【结 构 式】 |
【分子编号】21943 【品名】1-[bis(4-propylphenyl)methyl]-1H-benzimidazole-6-carboxylic acid 【CA登记号】 |
【 分 子 式 】C27H28N2O2 【 分 子 量 】412.5316 【元素组成】C 78.61% H 6.84% N 6.79% O 7.76% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(X)The intermediate benzimidazolecarboxylic acid (VI) cal also be obtained as follows: Alkylation of benzimidazole-5-carboxylic acid (VIII) with 4,4'-dipropylbenzhydryl bromide (XI) afforded a mixture of alkylated benzimidazoles (VI) and (X), which were separated by column chromatography.
【1】 Takami, H.; Kishibayashi, N.; Ishii, A.; Kumazawa, T.; Indole and benzimidazole derivatives as steroid 5alpha-reductase inhibitors in the rat prostate. Bioorg Med Chem 1998, 6, 12, 2441. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(VI) | 21939 | 1-[bis(4-propylphenyl)methyl]-1H-benzimidazole-5-carboxylic acid | C27H28N2O2 | 详情 | 详情 | |
(VIII) | 21941 | 1H-benzimidazole-5-carboxylic acid | 15788-16-6 | C8H6N2O2 | 详情 | 详情 |
(IX) | 21942 | 1-[bromo(4-propylphenyl)methyl]-4-propylbenzene | C19H23Br | 详情 | 详情 | |
(X) | 21943 | 1-[bis(4-propylphenyl)methyl]-1H-benzimidazole-6-carboxylic acid | C27H28N2O2 | 详情 | 详情 |
Extended Information