6-(2-oxo-2-phenylethoxy)-2(1H)-quinolinone -Drug Synthesis Database

【结构式】

【分子编号】21429

【品名】6-(2-oxo-2-phenylethoxy)-2(1H)-quinolinone

【CA登记号】

【分子式】C₁₇H₁₃NO₃

【分子量】279.29516

【元素组成】C 73.11% H 4.69% N 5.02% O 17.19%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

6-Hydroxyquinolin-2-one (I) was O-alkylated with 2-bromoacetophenone (II) by means of K2CO3 to give the phenacyl ether (III). Then, a Reformatsky-type condensation of (III) with ethyl 2-(bromomethyl)acrylate (IV) and Zn, with concomitant cyclization, yielded the target methylenebutyrolactone.

参考文献中间体

合成目标

【1】 Wang, T.-C.; et al.; alpha-Methylidene-gamma-butyrolactones: Synthesis and evaluation of quinolin-2(1H)-one derivatives. Helv Chim Acta 1998, 81, 6, 1038.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	13913	6-Hydroxy-2(1H)-quinolinone		C₉H₇NO₂	详情	详情
(II)	10315	2-Bromo-1-phenyl-ethanone; 2-Bromo-1-phenyl-1-ethanone	70-11-1	C₈H₇BrO	详情	详情
(III)	21429	6-(2-oxo-2-phenylethoxy)-2(1H)-quinolinone		C₁₇H₁₃NO₃	详情	详情
(IV)	11328	ethyl 2-(bromomethyl)acrylate	17435-72-2	C₆H₉BrO₂	详情	详情

Extended Information