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【结 构 式】 
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【药物名称】CCT-62 【化学名称】6-(4-Methylene-5-oxo-2-phenyltetrahydrofuran-2-ylmethoxy)quinolin-2(1H)-one 【CA登记号】210245-19-5 【 分 子 式 】C21H17NO4 【 分 子 量 】347.37394 |
【开发单位】Kaohsiung Medical College (Originator), National Taiwan University (Originator) 【药理作用】Antiplatelet Therapy, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, Phosphodiesterase III Inhibitors |
合成路线1
6-Hydroxyquinolin-2-one (I) was O-alkylated with 2-bromoacetophenone (II) by means of K2CO3 to give the phenacyl ether (III). Then, a Reformatsky-type condensation of (III) with ethyl 2-(bromomethyl)acrylate (IV) and Zn, with concomitant cyclization, yielded the target methylenebutyrolactone.
| 【1】 Wang, T.-C.; et al.; alpha-Methylidene-gamma-butyrolactones: Synthesis and evaluation of quinolin-2(1H)-one derivatives. Helv Chim Acta 1998, 81, 6, 1038. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13913 | 6-Hydroxy-2(1H)-quinolinone | C9H7NO2 | 详情 | 详情 | |
| (II) | 10315 | 2-Bromo-1-phenyl-ethanone; 2-Bromo-1-phenyl-1-ethanone | 70-11-1 | C8H7BrO | 详情 | 详情 |
| (III) | 21429 | 6-(2-oxo-2-phenylethoxy)-2(1H)-quinolinone | C17H13NO3 | 详情 | 详情 | |
| (IV) | 11328 | ethyl 2-(bromomethyl)acrylate | 17435-72-2 | C6H9BrO2 | 详情 | 详情 |
Extended Information