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【结 构 式】

【分子编号】21325

【品名】1-chloro-3-(4-fluorophenyl)indane

【CA登记号】

【 分 子 式 】C15H12ClF

【 分 子 量 】246.7113832

【元素组成】C 73.03% H 4.9% Cl 14.37% F 7.7%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The synthesis has been described by Bøgesø et al. and the absolute configuration has been determined by X-ray crystallography by Jensen.

1 Hyttel, J.; Bogeso, K.P.; Gundertofte, K.; Boeck, V.; Christensen, A.V.; Arnt, J.; Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity. J Med Chem 1988, 31, 12, 2247.
2 Jensen, B.; Structure of the (+)-tartrate of the selective 5-HT2 antagonist irindalon. Acta Cryst 1988, C44, 1602.
3 Boeck, V.; Bogeso, K.P.; Hyttel, J.; IRINDALONE TARTRATE < Rec INNM >. Drugs Fut 1989, 14, 9, 859.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 21325 1-chloro-3-(4-fluorophenyl)indane C15H12ClF 详情 详情
(II) 21326 1-[3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazine C19H21FN2 详情 详情
(III) 21327 1-(2-[4-[3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]-1-piperazinyl]ethyl)-2-imidazolidinone C24H29FN4O 详情 详情
(IV) 10355 Diethylenediamine; Piperazine 110-85-0 C4H10N2 详情 详情
(V) 21329 1-(2-chloroethyl)-2-imidazolidinone 2387-20-4 C5H9ClN2O 详情 详情
Extended Information