1-(2-[4-[3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]-1-piperazinyl]ethyl)-2-imidazolidinone -Drug Synthesis Database

【结构式】

【分子编号】21327

【品名】1-(2-[4-[3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]-1-piperazinyl]ethyl)-2-imidazolidinone

【CA登记号】

【分子式】C₂₄H₂₉FN₄O

【分子量】408.5190232

【元素组成】C 70.56% H 7.16% F 4.65% N 13.71% O 3.92%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The synthesis has been described by Bøgesø et al. and the absolute configuration has been determined by X-ray crystallography by Jensen.

【1】 Hyttel, J.; Bogeso, K.P.; Gundertofte, K.; Boeck, V.; Christensen, A.V.; Arnt, J.; Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity. J Med Chem 1988, 31, 12, 2247.
【2】 Jensen, B.; Structure of the (+)-tartrate of the selective 5-HT2 antagonist irindalon. Acta Cryst 1988, C44, 1602.
【3】 Boeck, V.; Bogeso, K.P.; Hyttel, J.; IRINDALONE TARTRATE < Rec INNM >. Drugs Fut 1989, 14, 9, 859.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	21325	1-chloro-3-(4-fluorophenyl)indane		C₁₅H₁₂ClF	详情	详情
(II)	21326	1-[3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazine		C₁₉H₂₁FN₂	详情	详情
(III)	21327	1-(2-[4-[3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]-1-piperazinyl]ethyl)-2-imidazolidinone		C₂₄H₂₉FN₄O	详情	详情
(IV)	10355	Diethylenediamine; Piperazine	110-85-0	C₄H₁₀N₂	详情	详情
(V)	21329	1-(2-chloroethyl)-2-imidazolidinone	2387-20-4	C₅H₉ClN₂O	详情	详情

Extended Information