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【结 构 式】

【分子编号】27751

【品名】methyl 1-methyl-1H-indole-2-carboxylate

【CA登记号】

【 分 子 式 】C11H11NO2

【 分 子 量 】189.21388

【元素组成】C 69.83% H 5.86% N 7.4% O 16.91%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

2-Indolecarboxylic acid (I) was esterified with MeOH and SOCl2 to provide methyl ester (II). Subsequent N-alkylation of (II) using methyl iodide and NaH afforded N-methyl indole (III). Guanidine, liberated by treatment of the hydrochloride salt with NaOMe, was finally condensed with indole ester (III) at 130 C to produce the corresponding acylguanidine, which was isolated as the mesylate salt.

1 Kojima, A.; Kitano, M.; Miyagishi, A.; Noguchi, T.; Yagi, H.; Nakano, K.; Ohashi, N. (Sumitomo Pharmaceuticals Co., Ltd.); Indoloylguanidine derivs. as inhibitors of sodium-hydrogen exchange. CA 2121391; EP 0622356; JP 1995010839 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 25226 1H-Indole-2-carboxylic acid; Indole-2-carboxylic acid 1477-50-5 C9H7NO2 详情 详情
(II) 27750 Indole-2-carboxylic acid methyl ester; 1H-indole-2-carboxylic acid methyl ester 1202-04-6 C10H9NO2 详情 详情
(III) 27751 methyl 1-methyl-1H-indole-2-carboxylate C11H11NO2 详情 详情
(IV) 14790 Guanidine 113-00-8 CH5N3 详情 详情
Extended Information