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【结 构 式】 
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【药物名称】SM-20220 【化学名称】N-(1-Methyl-1H-indol-2-ylcarbonyl)guanidine methanesulfonate 【CA登记号】 【 分 子 式 】C12H16N4O4S 【 分 子 量 】312.34972 |
【开发单位】Sumitomo Pharmaceuticals (Originator) 【药理作用】Cerebrovascular Diseases, Treatment of, Ischemic Stroke, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Na+/H+ Exchange (NHE) Inhibitors |
合成路线1
2-Indolecarboxylic acid (I) was esterified with MeOH and SOCl2 to provide methyl ester (II). Subsequent N-alkylation of (II) using methyl iodide and NaH afforded N-methyl indole (III). Guanidine, liberated by treatment of the hydrochloride salt with NaOMe, was finally condensed with indole ester (III) at 130 C to produce the corresponding acylguanidine, which was isolated as the mesylate salt.
| 【1】 Kojima, A.; Kitano, M.; Miyagishi, A.; Noguchi, T.; Yagi, H.; Nakano, K.; Ohashi, N. (Sumitomo Pharmaceuticals Co., Ltd.); Indoloylguanidine derivs. as inhibitors of sodium-hydrogen exchange. CA 2121391; EP 0622356; JP 1995010839 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25226 | 1H-Indole-2-carboxylic acid; Indole-2-carboxylic acid | 1477-50-5 | C9H7NO2 | 详情 | 详情 |
| (II) | 27750 | Indole-2-carboxylic acid methyl ester; 1H-indole-2-carboxylic acid methyl ester | 1202-04-6 | C10H9NO2 | 详情 | 详情 |
| (III) | 27751 | methyl 1-methyl-1H-indole-2-carboxylate | C11H11NO2 | 详情 | 详情 | |
| (IV) | 14790 | Guanidine | 113-00-8 | CH5N3 | 详情 | 详情 |
Extended Information