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【结 构 式】 
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【分子编号】24449 【品名】1-ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid 【CA登记号】 |
【 分 子 式 】C12H8F3NO3 【 分 子 量 】271.1956696 【元素组成】C 53.15% H 2.97% F 21.02% N 5.16% O 17.7% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(I)By condensation of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxilic acid (I) with 3-(ethylaminomethyl)pyrrolidone (II) by means of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in acetonitrile.
| 【1】 Culbertson, T.P.; Mich, T.F.; Domagala, J.M.; Nichols, J.B. (Pfizer Inc.); Antibacterial agents. EP 0106489; ES 8600934; JP 1989146880 . |
| 【2】 Prous, J.; Castaner, J.; CI-934. Drugs Fut 1986, 11, 5, 366. |
合成路线2
该中间体在本合成路线中的序号：(I)By condensation of 1-ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (I) with 2-methylpiperazine (II) in refluxing pyridine.
| 【1】 Itoh, Y.; Kato, H.; Koshinaka, E.; Ogawa, N.; Suzuki, T.; Yagi, N. (Hokuriku Seiyaku Co., Ltd.); Piperazinylquinoline-3-carboxylic acid derivs.. EP 0140116; ES 8604565; ES 8609303; FR 2555584; JP 1985064979; JP 1985190777; JP 1986005075 . |
| 【2】 Castaner, J.; Prous, J.; NY-198. Drugs Fut 1986, 11, 7, 578. |
Extended Information