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【结 构 式】 
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【药物名称】Lomefloxacin hydrochloride, SC-47111, NY-198, Okacin, Okacyn, Logiflox, Maxaquine, Maxaquin, Lomebact, Bareon, Uniquin 【化学名称】1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride 【CA登记号】98079-51-7 (free base), 114394-67-1 (mesylate salt) 【 分 子 式 】C17H20ClF2N3O3 【 分 子 量 】387.81705 |
【开发单位】Abbott (Originator), Unimed (Marketer), Beta (Licensee), Novartis Ophthalmics (Licensee), Pfizer (Licensee), Shionogi (Licensee) 【药理作用】Antibacterial Drugs, Antibacterial Ophthalmic Drugs, ANTIINFECTIVE THERAPY, Ocular Antiinflammatory and Antiinfective Agents, OCULAR MEDICATIONS, Ophthalmic Drugs, Quinolones |
合成路线1
By condensation of 1-ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (I) with 2-methylpiperazine (II) in refluxing pyridine.
| 【1】 Itoh, Y.; Kato, H.; Koshinaka, E.; Ogawa, N.; Suzuki, T.; Yagi, N. (Hokuriku Seiyaku Co., Ltd.); Piperazinylquinoline-3-carboxylic acid derivs.. EP 0140116; ES 8604565; ES 8609303; FR 2555584; JP 1985064979; JP 1985190777; JP 1986005075 . |
| 【2】 Castaner, J.; Prous, J.; NY-198. Drugs Fut 1986, 11, 7, 578. |