1-(2-hydroxyphenyl)-3-phenyl-1-propanone -Drug Synthesis Database

【结构式】

【分子编号】24436

【品名】1-(2-hydroxyphenyl)-3-phenyl-1-propanone

【CA登记号】42772-82-7

【分子式】C₁₅H₁₄O₂

【分子量】226.27496

【元素组成】C 79.62% H 6.24% O 14.14%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The condensation of 2'-hydroxy-3-phenylpropiophenone (I) with 1 chloro-2,3-epoxypropane (II) by means of K2CO3 gives 2'-(2,3-epoxypropoxy)-3-phenylpropiophenone (III), which is then treated with 2-methyl-2-aminobutane (IV) in refluxing methanol.

参考文献中间体

合成目标

【1】 Petrik, G.; Sachse, R. (Helopharm KG); 2-[2'-Hydroxy-3'-(1,1-dimethylpropylamino)-propoxy]-beta-phenylpropiophenone, its physiologically acceptable acid addition salts, and pharmaceutical compsns.. DE 3133814; US 4460605 .
【2】 Prous, J.; Castaner, J.; Difrafenone. Drugs Fut 1986, 11, 8, 645.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	24436	1-(2-hydroxyphenyl)-3-phenyl-1-propanone	42772-82-7	C₁₅H₁₄O₂	详情	详情
(II)	10146	Epichlorohydrin; 2-(Chloromethyl)oxirane	106-89-8	C₃H₅ClO	详情	详情
(III)	24438	1-[2-(2-oxiranylmethoxy)phenyl]-3-phenyl-1-propanone		C₁₈H₁₈O₃	详情	详情
(IV)	24439	2-methyl-2-butanamine	594-39-8	C₅H₁₃N	详情	详情

Extended Information