• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【药物名称】Diprafenone

【化学名称】(±)-2'-[2-Hydroxy-3-(tert-pentylamino)propoxy]-3-phenylpropiophenone

【CA登记号】81447-80-5, 86342-43-0 (HCl)

【 分 子 式 】C23H31NO3

【 分 子 量 】369.50842

【开发单位】Helopharm (Originator)

【药理作用】Antiarrhythmic Drugs, CARDIOVASCULAR DRUGS, beta-Adrenoceptor Antagonists

合成路线1

The condensation of 2'-hydroxy-3-phenylpropiophenone (I) with 1 chloro-2,3-epoxypropane (II) by means of K2CO3 gives 2'-(2,3-epoxypropoxy)-3-phenylpropiophenone (III), which is then treated with 2-methyl-2-aminobutane (IV) in refluxing methanol.

1 Petrik, G.; Sachse, R. (Helopharm KG); 2-[2'-Hydroxy-3'-(1,1-dimethylpropylamino)-propoxy]-beta-phenylpropiophenone, its physiologically acceptable acid addition salts, and pharmaceutical compsns.. DE 3133814; US 4460605 .
2 Prous, J.; Castaner, J.; Difrafenone. Drugs Fut 1986, 11, 8, 645.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 24436 1-(2-hydroxyphenyl)-3-phenyl-1-propanone 42772-82-7 C15H14O2 详情 详情
(II) 10146 Epichlorohydrin; 2-(Chloromethyl)oxirane 106-89-8 C3H5ClO 详情 详情
(III) 24438 1-[2-(2-oxiranylmethoxy)phenyl]-3-phenyl-1-propanone C18H18O3 详情 详情
(IV) 24439 2-methyl-2-butanamine 594-39-8 C5H13N 详情 详情
Extended Information