N-pentyl-1-pentanamine -Drug Synthesis Database

【结构式】

【分子编号】28751

【品名】N-pentyl-1-pentanamine

【CA登记号】2050-92-2

【分子式】C₁₀H₂₃N

【分子量】157.29936

【元素组成】C 76.36% H 14.74% N 8.9%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

The condensation of glutamic acid (I) with 3,4-dichlorobenzoyl chloride (II) by means of Na2CO3 in water gives N-(3,4-dichlorobenzoyl)glutamic acid (III), which is treated with acetic anhydride in refluxing isopropyl ether to afford N-(3,4-dichlorobenzoyl)glutamic anhydride (IV). Finally, this compound is treated with dipentylamine (V) in water.

参考文献中间体

合成目标

【1】 Zrenner, E.; Laties, A.M.; Eur J Med Chem - Chim Ther 1986, 21, 1, 9-20.
【2】 Chiste, R.; Makovec, F.; Rovati, L.A.; Pacini, M.A.; Bani, M.; Setnikar, I.; New glutaramic acid derivatives with potent competitive and specific cholecystokinin-antagonistic activity. Arzneim-Forsch Drug Res 1985, 35, 7, 1048-1051.
【3】 Rovati, L.C.; Chiste, R.; Bani, M.; Revel, L.; Makovec, F.; Rovati, L.A.; Differentiation of central and peripheral cholecystokinin receptors by new glutaramic acid derivatives with cholecystokinin-antagonistic activity. Arzneim-Forsch Drug Res 1986, 36, 1, 98-102.
【4】 Rovati, L.; Makovec, F.; Senin, P.; Chiste', R. (Rotta Research Laboratorium SpA); Derivatives of glutamic acid and aspartic acid. AU 8544109; BE 0902726; CH 674203; DE 3522506; ES 8604859; FR 2566397; GB 2160869; JP 1986044855; US 4791215 .
【5】 Castaner, J.; Serradell, M.N.; Castaner, R.M.; Lorglumide. Drugs Fut 1987, 12, 9, 851.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28752	DL-2-Amino propane dicarboxylic acid; DL-2-Aminopentanoic acid; glutamic acid; DL-glutamic acid; (+/-)-2-Aminoglutaric acid	617-65-2	C₅H₉NO₄	详情	详情
(II)	26356	3,4-dichlorobenzoyl chloride	3024-72-4	C₇H₃Cl₃O	详情	详情
(III)	28750	N-(3,4-dichlorobenzoyl)glutamic acid		C₁₂H₁₁Cl₂NO₅	详情	详情
(IV)	12129	3,4-Dichloro-N-(2,6-dioxotetrahydro-2H-pyran-3-yl)benzamide		C₁₂H₉Cl₂NO₄	详情	详情
(V)	28751	N-pentyl-1-pentanamine	2050-92-2	C₁₀H₂₃N	详情	详情

Extended Information