4-hydroxy-N-phenylbenzamide -Drug Synthesis Database

【结构式】

【分子编号】28206

【品名】4-hydroxy-N-phenylbenzamide

【CA登记号】

【分子式】C₁₃H₁₁NO₂

【分子量】213.23588

【元素组成】C 73.23% H 5.2% N 6.57% O 15.01%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of aniline (I) with 4-hydroxybenzoic acid (II) by means of P2O5 in refluxing toluene gives N-(4-hydroxybenzoyl)aniline (III), which is then condensed with pyrrolidine (IV) and formaldehyde (V) in refluxing ethanol.

参考文献中间体

合成目标

【1】 Stout, D.M.; et al.; Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 3. Modifications to the linkage region (Region 3(. J Med Chem 1985, 28, 3, 295-298.
【2】 Serradell, M.N.; Castaner, J.; ACC-9358. Drugs Fut 1986, 11, 3, 169.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12294	Aniline; Phenylamine	62-53-3	C₆H₇N	详情	详情
(II)	28208	3-thioxo-2,3-dihydro-1H-2H-thieno[3,4-d]isothiazole-1,1-dione		C₅H₃NO₂S₃	详情	详情
(III)	28206	4-hydroxy-N-phenylbenzamide		C₁₃H₁₁NO₂	详情	详情
(IV)	11376	Pyrrolidine	123-75-1	C₄H₉N	详情	详情
(V)	22075	Formaldehyde; Paraformaldehyde	1118-66-7	CH₂O	详情	详情

Extended Information