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【结 构 式】

【药物名称】DuP-923(diHCl), ACC-9358

【化学名称】2,6-Bis(N-pyrrolidinomethyl)-4-(phenylcarbamyl)phenol

【CA登记号】90446-66-5

【 分 子 式 】C23H29N3O2

【 分 子 量 】379.50648

【开发单位】American Hospital Supply (Originator), Bristol-Myers Squibb (Originator)

【药理作用】Antiarrhythmic Drugs, CARDIOVASCULAR DRUGS

合成路线1

The reaction of aniline (I) with 4-hydroxybenzoic acid (II) by means of P2O5 in refluxing toluene gives N-(4-hydroxybenzoyl)aniline (III), which is then condensed with pyrrolidine (IV) and formaldehyde (V) in refluxing ethanol.

1 Stout, D.M.; et al.; Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 3. Modifications to the linkage region (Region 3(. J Med Chem 1985, 28, 3, 295-298.
2 Serradell, M.N.; Castaner, J.; ACC-9358. Drugs Fut 1986, 11, 3, 169.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 12294 Aniline; Phenylamine 62-53-3 C6H7N 详情 详情
(II) 28208 3-thioxo-2,3-dihydro-1H-2H-thieno[3,4-d]isothiazole-1,1-dione C5H3NO2S3 详情 详情
(III) 28206 4-hydroxy-N-phenylbenzamide C13H11NO2 详情 详情
(IV) 11376 Pyrrolidine 123-75-1 C4H9N 详情 详情
(V) 22075 Formaldehyde; Paraformaldehyde 1118-66-7 CH2O 详情 详情
Extended Information