2-chloro-N-(3,4-dimethoxyphenethyl)acetamide -Drug Synthesis Database

【结构式】

【分子编号】20955

【品名】2-chloro-N-(3,4-dimethoxyphenethyl)acetamide

【CA登记号】

【分子式】C₁₂H₁₆ClNO₃

【分子量】257.71668

【元素组成】C 55.93% H 6.26% Cl 13.76% N 5.43% O 18.62%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

The reaction of 3-nitrobenzoic acid (I) with refluxing SOCl2 gives the corresponding acyl chloride (II), which by reaction with methylamine in chloroform is converted to the methylamide (III). The reduction of (III) with H2 over RaNi in methanol yields the 3-amino-N-methylbenzamide (IV), which is finally condensed with 2-chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (V) by means of NaI and CaCO3 in hot DMF.

参考文献中间体

合成目标

【1】 Miki, T.; Asano, M.; Hosokami, T. (Daiichi Seiyaku Co.; Ltd.); Aminobenzamide derivatives. EP 0185368 .
【2】 Prous, J.; Castaner, J.; DQ-2511. Drugs Fut 1989, 14, 7, 620.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	20951	2-nitrobenzoic acid；o-Nitrobenzoic acid	552-16-9	C₇H₅NO₄	详情	详情
(II)	21099	o-nitrobenzoyl chloride; 2-nitrobenzoyl chloride	610-14-0	C₇H₄ClNO₃	详情	详情
(III)	20953	N-methyl-2-nitrobenzamide		C₈H₈N₂O₃	详情	详情
(IV)	20954	2-amino-N-methylbenzamide	4141-08-6	C₈H₁₀N₂O	详情	详情
(V)	20955	2-chloro-N-(3,4-dimethoxyphenethyl)acetamide		C₁₂H₁₆ClNO₃	详情	详情

Extended Information