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【结 构 式】

【分子编号】20950

【品名】ethyl 4-[(6-chloro-2-pyridinyl)sulfanyl]-1-piperidinecarboxylate

【CA登记号】

【 分 子 式 】C13H17ClN2O2S

【 分 子 量 】300.80896

【元素组成】C 51.91% H 5.7% Cl 11.79% N 9.31% O 10.64% S 10.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

2,6-Dichloropyridine (I) reacts with sodium hydrogen sulfide yielding 6-chloro-2-mercaptopyridine sodium salt (II). The thioether (III) is formed through reaction of 4-chloro-N-methylpiperidine with (II). Cleavage of the N-methyl group is achieved by condensation of (III) with ethyl chloroformate followed by acidic hydrolysis.

1 Engel, J.; Jacovlev, V.; Nickel, B.; Scheffler, G.; Thiemer, K. (Degussa-Hüls AG); New pyridine-2-ethers and pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring. DE 3443968; EP 0149088; ES 8607014; GB 2152048; JP 1985169476; US 4643995 .
2 Szelenyi, I.; Engel, J.; Scheffler, G.; Nickel, B.; Thiemer, K.; Tibes, U.; Werner, U.; ANPIRTOLINE HYDROCHLORIDE < Rec INNM >. Drugs Fut 1989, 14, 7, 614.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 13573 2,6-Dichloropyridine 2402-78-0 C5H3Cl2N 详情 详情
(II) 20947 6-Chloropyridine-2-thiol sodium salt C5H3ClNNaS 详情 详情
(III) 20948 6-chloro-2-pyridinyl 1-methyl-4-piperidinyl sulfide; 4-[(6-chloro-2-pyridinyl)sulfanyl]-1-methylpiperidine C11H15ClN2S 详情 详情
(IV) 20949 4-Chloro-1-methylpiperidine; 4-Chloro-N-methylpiperidine; N-methyl-4-chloropiperidine 55770-77-4 C6H12ClN 详情 详情
(V) 20950 ethyl 4-[(6-chloro-2-pyridinyl)sulfanyl]-1-piperidinecarboxylate C13H17ClN2O2S 详情 详情
Extended Information