【结 构 式】 |
【分子编号】20950 【品名】ethyl 4-[(6-chloro-2-pyridinyl)sulfanyl]-1-piperidinecarboxylate 【CA登记号】 |
【 分 子 式 】C13H17ClN2O2S 【 分 子 量 】300.80896 【元素组成】C 51.91% H 5.7% Cl 11.79% N 9.31% O 10.64% S 10.66% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(V)2,6-Dichloropyridine (I) reacts with sodium hydrogen sulfide yielding 6-chloro-2-mercaptopyridine sodium salt (II). The thioether (III) is formed through reaction of 4-chloro-N-methylpiperidine with (II). Cleavage of the N-methyl group is achieved by condensation of (III) with ethyl chloroformate followed by acidic hydrolysis.
【1】 Engel, J.; Jacovlev, V.; Nickel, B.; Scheffler, G.; Thiemer, K. (Degussa-Hüls AG); New pyridine-2-ethers and pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring. DE 3443968; EP 0149088; ES 8607014; GB 2152048; JP 1985169476; US 4643995 . |
【2】 Szelenyi, I.; Engel, J.; Scheffler, G.; Nickel, B.; Thiemer, K.; Tibes, U.; Werner, U.; ANPIRTOLINE HYDROCHLORIDE < Rec INNM >. Drugs Fut 1989, 14, 7, 614. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 13573 | 2,6-Dichloropyridine | 2402-78-0 | C5H3Cl2N | 详情 | 详情 |
(II) | 20947 | 6-Chloropyridine-2-thiol sodium salt | C5H3ClNNaS | 详情 | 详情 | |
(III) | 20948 | 6-chloro-2-pyridinyl 1-methyl-4-piperidinyl sulfide; 4-[(6-chloro-2-pyridinyl)sulfanyl]-1-methylpiperidine | C11H15ClN2S | 详情 | 详情 | |
(IV) | 20949 | 4-Chloro-1-methylpiperidine; 4-Chloro-N-methylpiperidine; N-methyl-4-chloropiperidine | 55770-77-4 | C6H12ClN | 详情 | 详情 |
(V) | 20950 | ethyl 4-[(6-chloro-2-pyridinyl)sulfanyl]-1-piperidinecarboxylate | C13H17ClN2O2S | 详情 | 详情 |
Extended Information