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【结 构 式】 
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【分子编号】20781 【品名】3-chloro-1-propanamine; 3-chloropropylamine 【CA登记号】14753-26-5 |
【 分 子 式 】C3H8ClN 【 分 子 量 】93.55596 【元素组成】C 38.51% H 8.62% Cl 37.89% N 14.97% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The reaction of 4-nitrobenzoyl chloride (I) with 3-chloropropylamine (II) by menas of triethylamine in dichloromethane gives the corresponding amide (III), which is then condensed with 2-(3,4-dimethoxyphenyl)ethylamine (IV) by means of triethylamine in refluxing dichloromethane.
| 【1】 Nadler, G.M.M.G.; Martin, M.J.R. (SmithKline Beecham plc); Nitro-benzamides useful as anti-arrhythmic agents. EP 0788474; FR 2726267; JP 1998508013; US 5977179; WO 9613479 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18941 | p-nitrobenzoyl chloride; 4-nitrobenzoyl chloride | 122-04-3 | C7H4ClNO3 | 详情 | 详情 |
| (II) | 20781 | 3-chloro-1-propanamine; 3-chloropropylamine | 14753-26-5 | C3H8ClN | 详情 | 详情 |
| (III) | 20782 | N-(3-chloropropyl)-4-nitrobenzamide | C10H11ClN2O3 | 详情 | 详情 | |
| (IV) | 10098 | 2-(3,4-Dimethoxyphenyl)-1-ethanamine; 3,4-Dimethoxyphenethylamine; 2-(3,4-Dimethoxyphenyl)ethylamine | 120-20-7 | C10H15NO2 | 详情 | 详情 |
Extended Information