tert-butyl(methylidyne)-lambda(5)-azane -Drug Synthesis Database

【结构式】

【分子编号】20480

【品名】tert-butyl(methylidyne)-lambda(5)-azane

【CA登记号】

【分子式】C₅H₁₁N

【分子量】85.14908

【元素组成】C 70.53% H 13.02% N 16.45%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of 2(R)-(2,2-dimethyl-5-oxo-1,3-dioxolan-4(S)-yl)-4,4-dimethylpentanoic acid (I) with 2,2-dimethylpropanal (II), ter-butyl isocyanide (III) and ammonia in methanol gives the intermediate (IV), which, without isolation is treated with hydroxylamine to yield the target compound as a mixture of diastereomers.

参考文献中间体

合成目标

【1】 Flygare, J.; Medina, J.; Shan, B.; Clark, D.; Rosen, T. (Tularik Inc.); Pentafluorobenzenesulfonamides and analogs. EP 0939627; WO 9805315 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	20478	(2R)-2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-4-methylpentanoic acid		C₁₁H₁₈O₅	详情	详情
(II)	19797	Trimethylacetaldehyde; pivalaldehyde; 2,2-Dimethylpropionaldehyde; 2,2-Dimethylpropanal	630-19-3	C₅H₁₀O	详情	详情
(III)	20480	tert-butyl(methylidyne)-lambda(5)-azane		C₅H₁₁N	详情	详情
(IV)	20481	(2R)-N-[1-[(tert-butylamino)carbonyl]-2,2-dimethylpropyl]-2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-4-methylpentanamide		C₂₁H₃₈N₂O₅	详情	详情

Extended Information