【结 构 式】 |
【分子编号】20478 【品名】(2R)-2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-4-methylpentanoic acid 【CA登记号】 |
【 分 子 式 】C11H18O5 【 分 子 量 】230.26092 【元素组成】C 57.38% H 7.88% O 34.74% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)The condensation of 2(R)-(2,2-dimethyl-5-oxo-1,3-dioxolan-4(S)-yl)-4,4-dimethylpentanoic acid (I) with 2,2-dimethylpropanal (II), ter-butyl isocyanide (III) and ammonia in methanol gives the intermediate (IV), which, without isolation is treated with hydroxylamine to yield the target compound as a mixture of diastereomers.
【1】 Flygare, J.; Medina, J.; Shan, B.; Clark, D.; Rosen, T. (Tularik Inc.); Pentafluorobenzenesulfonamides and analogs. EP 0939627; WO 9805315 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 20478 | (2R)-2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-4-methylpentanoic acid | C11H18O5 | 详情 | 详情 | |
(II) | 19797 | Trimethylacetaldehyde; pivalaldehyde; 2,2-Dimethylpropionaldehyde; 2,2-Dimethylpropanal | 630-19-3 | C5H10O | 详情 | 详情 |
(III) | 20480 | tert-butyl(methylidyne)-lambda(5)-azane | C5H11N | 详情 | 详情 | |
(IV) | 20481 | (2R)-N-[1-[(tert-butylamino)carbonyl]-2,2-dimethylpropyl]-2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-4-methylpentanamide | C21H38N2O5 | 详情 | 详情 |
Extended Information