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【结 构 式】

【分子编号】20478

【品名】(2R)-2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-4-methylpentanoic acid

【CA登记号】

【 分 子 式 】C11H18O5

【 分 子 量 】230.26092

【元素组成】C 57.38% H 7.88% O 34.74%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The condensation of 2(R)-(2,2-dimethyl-5-oxo-1,3-dioxolan-4(S)-yl)-4,4-dimethylpentanoic acid (I) with 2,2-dimethylpropanal (II), ter-butyl isocyanide (III) and ammonia in methanol gives the intermediate (IV), which, without isolation is treated with hydroxylamine to yield the target compound as a mixture of diastereomers.

1 Flygare, J.; Medina, J.; Shan, B.; Clark, D.; Rosen, T. (Tularik Inc.); Pentafluorobenzenesulfonamides and analogs. EP 0939627; WO 9805315 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 20478 (2R)-2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-4-methylpentanoic acid C11H18O5 详情 详情
(II) 19797 Trimethylacetaldehyde; pivalaldehyde; 2,2-Dimethylpropionaldehyde; 2,2-Dimethylpropanal 630-19-3 C5H10O 详情 详情
(III) 20480 tert-butyl(methylidyne)-lambda(5)-azane C5H11N 详情 详情
(IV) 20481 (2R)-N-[1-[(tert-butylamino)carbonyl]-2,2-dimethylpropyl]-2-[(4R)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]-4-methylpentanamide C21H38N2O5 详情 详情
Extended Information