【结 构 式】 |
【分子编号】20080 【品名】4-[N-(2,4-Diaminopteridin-6-ylmethyl)-N-formylamino]benzoic acid isobutoxycarbonyl anhydride 【CA登记号】 |
【 分 子 式 】C20H21N7O5 【 分 子 量 】439.43092 【元素组成】C 54.67% H 4.82% N 22.31% O 18.2% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XV)2) Alternatively, N10-formyl-4-amino-4-deoxypteroic acid (VII), prepared as before, was converted to the mixed anhydride (XV) with isobutyl chloroformate and triethylamine, and subsequently condensed with the Na,O-bis(trimethylsilyl) derivative of Nd-phthaloyl-L-ornithine (XVI) to give amide (XVII). Then, hydrolysis of the formamide function and concomitant phthalimide ring opening with aqueous NaOH provided the target compound.
【1】 Rosowsky, A.; et al.; Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folypolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain. J Med Chem 1986, 29, 655. |
【2】 Rosowsky, A.; et al.; Methotrexate analogues. 25. Chemical and biological studies on the gamma-tert-butyl esters of methotrexate and aminopterin. J Med Chem 1985, 28, 5, 660. |
【3】 Rosowsky, A.; et al.; Methotrexate analogues. 33. Ndelta-Acyl-Nalpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: Synthesis and in vitro antitumor activity. J Med Chem 1988, 31, 1332-7. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(VII) | 20072 | 4-[[(2,4-diamino-6-pteridinyl)methyl](formyl)amino]benzoic acid | C15H13N7O3 | 详情 | 详情 | |
(XV) | 20080 | 4-[N-(2,4-Diaminopteridin-6-ylmethyl)-N-formylamino]benzoic acid isobutoxycarbonyl anhydride | C20H21N7O5 | 详情 | 详情 | |
(XVI) | 20081 | trimethylsilyl (2S)-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[(trimethylsilyl)amino]pentanoate | C19H30N2O4Si2 | 详情 | 详情 | |
(XVII) | 20082 | (2S)-2-([4-[[(2,4-diamino-6-pteridinyl)methyl](formyl)amino]benzoyl]amino)-5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pentanoic acid | C28H25N9O6 | 详情 | 详情 |
Extended Information