|
【结 构 式】 
|
【分子编号】19903 【品名】ethyl 6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate 【CA登记号】 |
【 分 子 式 】C12H10FNO3 【 分 子 量 】235.2147432 【元素组成】C 61.28% H 4.29% F 8.08% N 5.95% O 20.41% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(I)Title compound was synthesized by condensation of ethyl 6-fluoro-4-quinolone-3-carboxylate (I) with cyclohexylamine (II) in pyridine at 120 C under pressure.
| 【1】 Srivastava S; Srivastava, S.K.; Shukla, A.; Chauhan, P.M.; Puri, S.K.; Bhaduri, A.P.; Pandey, V.C.; Synthesis and methemoglobin toxicity of the amides of 6/7 mono or disubstituted quinolone. Bioorg Med Chem Lett 1999, 9, 1, 25. |
合成路线2
该中间体在本合成路线中的序号：(I)Title compound was synthesized by condensation of ethyl 6-fluoro-4-quinolone-3-carboxylate (I) with N-methylpiperazine (II) in pyridine at 120 C under pressure.
| 【1】 Srivastava S; Srivastava, S.K.; Shukla, A.; Chauhan, P.M.; Puri, S.K.; Bhaduri, A.P.; Pandey, V.C.; Synthesis and methemoglobin toxicity of the amides of 6/7 mono or disubstituted quinolone. Bioorg Med Chem Lett 1999, 9, 1, 25. |
Extended Information